Lineage Cell Therapeutics, Inc.
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About the company
Lineage Cell Therapeutics, Inc. operates as a clinical-stage biotechnology company developing new cellular therapies for degenerative retinal diseases, neurological conditions associated with demyelination, and aiding the body in detecting and combating cancer. The company's programs are based on two core proprietary technology platforms: cell replacement and cell and drug delivery.
- CEO
- Brian Culley
- IPO
- 2015
- Employees
- 75
- HQ
- Carlsbad, CA, US
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- Market Cap
- $831.41M
- P/E
- -7.70
- Fwd P/E
- 41787.11
- PEG
- 0.19
- P/S
- 20.58
- P/B
- 4.42
- EV/EBITDA
- -6.39
- Div Yield
- 0.00%
- Gross Margin
- 96.59%
- Op Margin
- -205.23%
- Net Margin
- -246.58%
- ROE
- -71.14%
- ROIC
- -23.25%
Latest fiscal year · YoY change
- Revenue
- $14.56M+53.2%
- Gross Profit
- $13.71M+49.6%
- Op Income
- $-21,778,999
- Net Income
- $-63,532,999-241.4%
- EPS
- $-0.28-184.0%
- OCF Growth
- +18.1%
- FCF Growth
- +17.8%
- 52W High
- $435.00
- 52W Low
- $3.61
- 50D MA
- $361.16
- 200D MA
- $124.56
- Beta
- 1.55
- RSI (14)
- 47
- Avg Volume
- 4.59K
Earnings call summaries
Pick a quarter — each call distilled into takeaways, results, and a bull vs bear read.
Lineage highlighted rapid progress across its internal cell-therapy pipeline while reiterating confidence in OpRegen and extending cash runway into the third quarter of 2028.· August 6, 2026
- Cash, cash equivalents and marketable securities were $50.8 million at June 30, 2026, with runway expected into Q3 2028.
- Second-quarter revenue was $1.1 million, down from $2.8 million a year ago; net income was $1.5 million, or $0.01 per basic share and a $0.03 loss per diluted share, versus a $30.5 million loss last year.
- Management emphasized Lineage 3.0: building internally owned programs in cornea, diabetes, hearing loss, and spinal cord injury using the AlloSCOPE platform.
- COR1 advanced into preclinical testing with initial in vivo data targeted by year-end; ReSonance completed 3 engineering runs and its first GMP run; ILT1 moved to a larger multi-tier format.
- OpRegen remains the lead partnered asset, with Roche/Genentech continuing surgical optimization and broader program activity seen as supportive, but management gave no new clinical timeline.
Total revenues were $1.1 million, down $1.7 million from $2.8 million in the same period of 2025. Total operating expenses were $10 million, down $12.5 million from $22.5 million in the prior-year quarter, mainly because the prior year included a $14.8 million noncash impairment charge. R&D expense was $4.8 million versus $3.1 million a year ago, and G&A expense was $5.2 million versus approximately $4.5 million. Loss from operations was $8.9 million versus $19.8 million a year ago. Other income was $10.5 million versus other expense of $10.6 million last year, driven largely by the quarterly fair value remeasurement of warrant liabilities. Net income attributable to Lineage was $1.5 million, or $0.01 per basic share and a $0.03 loss per diluted share, versus a net loss of $30.5 million, or $0.13 per share, in Q2 2025. As of June 30, 2026, cash, cash equivalents and marketable securities were $50.8 million, expected to fund operations into Q3 2028. Management said it raised approximately $4.6 million on June 26 at a weighted average price of $1.28 per share. They also cited approximately $32 million of potential warrant proceeds, up to $615 million of potential Roche milestone payments, and additional partnership opportunities. No quarterly revenue or EPS guidance was provided.
Brian Culley framed the quarter around what he called Lineage 3.0: using the AlloSCOPE platform to generate a broader, more internally owned pipeline rather than relying solely on OpRegen. He repeatedly stressed manufacturing as the core competitive advantage, arguing that Lineage is building programs with scalable, controlled production from the start. His tone was confident and explanatory, with a strong emphasis on the difficulty of cell-therapy manufacturing and the value of proving scale early.
Jill Howe focused on the balance sheet and the quarter’s accounting-driven results. She said the company had $50.8 million in cash, cash equivalents and marketable securities and expects that to fund operations into Q3 2028, helped by the $4.6 million ATM sale on Russell Reconstitution Day at a $1.28 weighted average price. She also cited approximately $32 million of potential warrant proceeds, up to $615 million of Roche milestone payments, and described the quarter’s net income as being largely driven by a noncash gain from warrant-liability remeasurement plus foreign exchange effects. Operating discipline and prudent capital allocation were highlighted as ongoing priorities.
Analysts focused on the diabetes and spinal cord injury programs, COR1 timing, and OpRegen milestones and rights. Management declined to disclose the specific multiliter scale for the diabetes program, saying they want to protect the platform’s know-how, but said the work had progressed to a larger multi-tier format and that more updates are likely before year-end. On DOSED, management said the first four patients each require a one-month DSMB break, the third patient is being assessed, all current candidates are chronic patients, and the goal is to complete remaining patients within roughly 12 months. On OpRegen, Brian Culley reiterated the $615 million in potential development and commercial milestones, said the company has a double-digit royalty structure rather than co-promote rights, and explained that the EMA IRIS registration was an administrative step, not a commitment by Roche or Genentech to proceed in Europe.
The call showed tangible progress across multiple internal assets, including COR1 moving into preclinical testing, ReSonance completing GMP work, and ILT1 advancing its scale-up process. Management believes these programs fit a model where small trials could generate meaningful signals, and they stressed that the platform can create novel assets without materially increasing annual investment.
Several programs are still early and preclinical, and management gave no clinical data for COR1, ReSonance, or ILT1 beyond process milestones. OpRegen still depends on Roche/Genentech’s optimization work, and management offered only interpretive “tea leaves,” not a firm timeline, while the DOSED study remains limited by DSMB pacing and patient recruitment constraints.
AI summary of the company's earnings call · Paraphrased · Not investment advice
- Free Float
- 94.9%
- Shares Outstanding
- 249.30M
- Float Shares
- 236.53M
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