Phio Pharmaceuticals Corp.
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About the company
Phio Pharmaceuticals Corp. , a clinical stage biopharmaceutical company, engages in the development of immuno-oncology therapeutics in the United States. It develops PH-762, an INTASYL compound designed to reduce the expression of PD-1 in multi-center Phase 1b dose-escalating clinical trials; PH-894, an INTASYL compound that is designed to specifically silence BRD4, a protein that controls gene expression in both T cells and tumor cells in preclinical studies.
- CEO
- Robert L. Bitterman
- IPO
- 2012
- Employees
- 6
- HQ
- King of Prussia, PA, US
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- Market Cap
- $14.06M
- P/E
- -0.90
- PEG
- -0.01
- P/S
- 0.00
- P/B
- 1.12
- EV/EBITDA
- -0.08
- Div Yield
- 0.00%
- Gross Margin
- 0.00%
- Op Margin
- 0.00%
- Net Margin
- 0.00%
- ROE
- -87.41%
- ROIC
- -100.51%
Latest fiscal year · YoY change
- Revenue
- $0+0.0%
- Gross Profit
- $-4,618,000-26.8%
- Op Income
- $-9,220,000
- Net Income
- $-8,698,000-21.7%
- EPS
- $-1.45-59.3%
- OCF Growth
- -12.2%
- FCF Growth
- -12.3%
- 52W High
- $4.19
- 52W Low
- $0.81
- 50D MA
- $1.04
- 200D MA
- $1.15
- Beta
- 0.79
- RSI (14)
- 67
- Avg Volume
- 614.93K
Earnings call summaries
Pick a quarter — each call distilled into takeaways, results, and a bull vs bear read.
RXi reported lower third-quarter losses on reduced spending, strengthened cash with a $15 million financing, and is refocusing on immuno-oncology as it works to regain NASDAQ compliance.· November 14, 2018
- Q3 net loss improved to $1.5 million from $2.5 million a year ago as spending came down.
- R&D expense fell to $0.8 million from $1.5 million, and G&A fell to $0.7 million from $1.0 million.
- The company said it ended the quarter with $3.2 million in cash and, after an October offering, expects funding into the second half of 2020.
- Management is pursuing sales or out-licensing of dermatology and ophthalmology assets, with interest described as good in dermatology and excellent in ophthalmology.
- The company announced a name change to Phio Pharmaceuticals and said its focus is now squarely on its RNAi platform for immuno-oncology and adoptive cell therapy.
For the quarter ended September 30, 2018, RXi reported grant revenues of $57,000, versus no such revenue in the prior-year quarter. R&D expense was $0.8 million, down from $1.5 million year over year, and G&A expense was $0.7 million, down from $1.0 million year over year. Net loss was $1.5 million versus $2.5 million in the same quarter of 2017. Cash was $3.2 million at September 30, 2018, compared with $3.6 million at December 31, 2017. After quarter-end, the company completed an underwritten public offering that raised $15 million gross and about $13.3 million net, and management said this provides an additional 6 to 7 quarters of cash and should fund operations into the second half of 2020. Management also said burn has been around $2 million per quarter and expects that to continue early next year, with costs likely to start increasing toward the end of 2019 as the company moves into the clinic.
Geert Cauwenbergh said the quarter reflected improved finances, lower losses, and an extended cash runway after the financing. He emphasized that the company is actively working to sell or out-license dermatology and ophthalmology assets to bring in non-dilutive cash, and said the process has accelerated as final clinical data became available. He also framed the company’s strategic shift around the upcoming name change to Phio Pharmaceuticals, saying it better reflects the company’s commitment to its self-delivering RNAi platform in immuno-oncology.
Caitlin Kontulis walked through the quarter’s financial decline in spend, noting grant revenue of $57,000, R&D of $0.8 million, G&A of $0.7 million, and net loss of $1.5 million. She said the lower expenses were mainly due to reduced clinical-trial activity and lower payroll tied to headcount reductions. On liquidity, she said cash was $3.2 million at quarter-end, the October offering added $15 million gross and about $13.3 million net, and the company believes it now has sufficient cash to fund operations into the second half of 2020; she also said the company expects about a $2 million quarterly burn early next year, with spending ramping later as clinical work begins.
Analysts focused on cash burn, the timing of higher expenses as the company approaches the clinic, and the status of the dermatology/ophthalmology monetization process. Management said burn should stay around $2 million per quarter at the start of next year, then likely rise toward the end of 2019 as clinical development ramps. On asset sales, management said it could not give a valuation range because there is active due diligence and different dynamics between dermatology and ophthalmology, but described interest as strong and said the company wants to maximize terms rather than rush a deal. They also addressed NASDAQ compliance, saying the company must regain a $1 closing price for 10 consecutive business days by May 13, 2019, and that the name change was not intended to affect short sellers or force buybacks.
The company is now funded for a longer runway, with management pointing to cash coverage into the second half of 2020 and possible additional upside from licensing or collaboration deals. On the science side, management described multiple collaborations and said internal NK-cell work showed up to 95% suppression of certain checkpoint targets, along with strong interest from conference audiences and partners.
The shares remain below $1, creating NASDAQ compliance risk, and management acknowledged they may need further time or actions if the stock does not recover. The company also said spending should rise as it moves toward clinical trials, and the asset-sale process is still ongoing with no deal value or timing disclosed.
AI summary of the company's earnings call · Paraphrased · Not investment advice
- Free Float
- 99.3%
- Shares Outstanding
- 11.62M
- Float Shares
- 11.54M
of shares held by institutions
17 13F filers
Buy/sell ratio 0.00. Sells can include pre-scheduled 10b5-1 plan sales, not just discretionary selling.
Top institutional holders
Largest 13F positions, with quarter-over-quarter change.
| Holder | Shares | Δ Quarter |
|---|---|---|
| Vanguard Group Inc | 87.63K | 0 |
Held by 4 ETFs
Biggest fund positions in PHIO by dollar value.
Recent insider transactions
Who's buying, who's selling, and how much.
| Date | Insider | Type | Shares |
|---|---|---|---|
| Aug 19, 26 | Plott Ronald Todd | buy | 15,000 |
| Aug 18, 26 | Bitterman Robert J | buy | 10,000 |
| Jul 20, 26 | Plott Ronald Todd | other | 0 |
| Jun 26, 26 | Bitterman Robert J | buy | 10,000 |
| Feb 5, 26 | Lockshin Curtis | other | 16,600 |
| Feb 5, 26 | Freeman Jonathan E | other | 16,600 |
| Feb 5, 26 | Deming David H | other | 23,800 |
| Feb 5, 26 | Carson Lisa Cabott | other | 47,000 |
| Feb 5, 26 | BRADFORD PATRICIA A | other | 18,500 |
| Feb 5, 26 | Bitterman Robert J | other | 120,000 |
A “Sell” may be a pre-scheduled 10b5-1 plan sale rather than a discretionary decision — read insider selling with that in mind.
Our PHIO coverage
Recent articles, reports, and earnings notes.
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Generate PHIO report →Phio Pharmaceuticals Secures U.S. Notice of Allowance for INTASYL Composition Selectively Targeting BRD4 Protein with Compound PH-894
feeds.newsfilecorp.com · Aug 11
Phio Pharmaceuticals Reports Second Quarter 2026 Financial Results and Business Update
newsfilecorp.com · Aug 6
Correction to Announcement Regarding Phio Pharmaceuticals Participation in the Renmark Financial Communications Live Virtual Non-Deal Roadshow Series
newsfilecorp.com · Jul 22
Phio Pharmaceuticals Announces Participation in the Renmark Financial Communications Live Virtual Non-Deal Roadshow Series
newsfilecorp.com · Jul 22
Phio Pharmaceuticals Announces Appointment of Dr. R. Todd Plott to the Board of Directors
newsfilecorp.com · Jul 21
Phio Pharmaceuticals Announces Patent Milestone with Multiple Notices of Allowance and Grant Decision
newsfilecorp.com · Jul 15
Phio Pharmaceuticals Announces Participation in the Renmark Financial Communications Live Virtual Non-Deal Roadshow Series
newsfilecorp.com · Jun 26
Phio Pharmaceuticals Announces "How siRNA Therapy can Change the Course of Cancer Treatment" in a Fireside Chat with Force Family Office on Monday, June 29, 2026
feeds.newsfilecorp.com · Jun 25
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