Provectus Biopharmaceuticals, Inc.
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About the company
Provectus Biopharmaceuticals, Inc. is a clinical-stage biotechnology firm dedicated to pioneering immunotherapy treatments. These therapies are grounded in its proprietary halogenated xanthene platform.
- CEO
- Edward V. Pershing
- IPO
- 1997
- Employees
- 6
- HQ
- Knoxville, TN, US
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Similar companies
Peers in the same neighborhood.
- Market Cap
- $23.14M
- P/E
- -4.87
- PEG
- -0.19
- P/S
- 0.00
- P/B
- -3.68
- EV/EBITDA
- -6.43
- Div Yield
- 0.00%
- Gross Margin
- 0.00%
- Op Margin
- 0.00%
- Net Margin
- 0.00%
- ROE
- 74.53%
- ROIC
- 268.74%
Latest fiscal year · YoY change
- Revenue
- $336.11K-45.5%
- Gross Profit
- $334.25K-45.2%
- Op Income
- $-4,844,269
- Net Income
- $-5,430,851-14.7%
- EPS
- $-0.01-14.2%
- OCF Growth
- -1.3%
- FCF Growth
- -1.3%
- 52W High
- $0.09
- 52W Low
- $0.04
- 50D MA
- $0.06
- 200D MA
- $0.06
- Beta
- 0.87
- RSI (14)
- 40
- Avg Volume
- 157.85K
Earnings call summaries
Pick a quarter — each call distilled into takeaways, results, and a bull vs bear read.
Provectus said its long-term value still hinges on Rose Bengal Sodium and highlighted a new ophthalmology spinout, while advancing multiple low-cost collaborations and next-step regulatory plans.· November 14, 2024
- Management framed Rose Bengal Sodium as the core asset and said Provectus is the world’s sole provider of pharmaceutical-grade RBS API.
- The lead cancer program is mPDAC, with a goal to secure an FDA Type C meeting in the first half of 2025 before working with Moffitt on patient enrollment.
- A new ophthalmology startup (NewCo/EyeCo) is being formed to pursue infectious keratitis, with a seed round targeted this quarter and up to $3 million in milestone-based funding.
- Management said the ophthalmology program could be materially non-dilutive for Provectus and may create a higher valuation for the subsidiary and, indirectly, Provectus.
- Other research tracks remain active, including a planned large-animal dermatology/wound-care study in Q1 2025 and a refocused canine-cancer effort.
The call did not report quarterly revenue, EPS, or gross margin figures. Management did not provide financial statements or year-over-year operating results on this investor update. Forward plans included seeking an FDA Type C Meeting for mPDAC in the first half of 2025, launching NewCo/EyeCo and closing a seed round this quarter, pursuing a pre-IND meeting for the ophthalmology program in the first half of 2025, and starting a large-animal study in Q1 2025. Management also said NewCo’s seed round would be up to $3 million in milestone-based tranches, with a post-money valuation range of $20 million to $33 million, and that NewCo may raise up to another $3 million on similar terms.
Ed Pershing emphasized that Provectus’ value is tied to the therapeutic and strategic potential of Rose Bengal Sodium, not just near-term financial metrics. He argued the company’s model is becoming more flexible and more valuable through structures like the ophthalmology spinout, which he described as a way to capture non-dilutive capital and potentially increase shareholder value. His tone was confident and promotional, but he also repeatedly stressed prudence around time, risk, and resources.
No CFO prepared remarks were given, and no standard financial discussion such as cash balance, burn, margins, or capital allocation metrics was reported. The closest financial commentary came from management’s statements that the ophthalmology spinout could raise up to $3 million initially, potentially another $3 million later, and that the structure could be a non-dilutive way to fund development. Management also said the company is trying to pursue programs that require minimal financial resources while creating potential future upside.
Analysts focused on collaboration opportunities, timing, recruitment, the canine program, the status of POETIC, Australia, the bridge study concept, and what entity would be needed for EyeCo. Management said mPDAC remains the key partnership-focused program, that trial timing depends on FDA clearance and is expected to begin within a quarter or two after clearance, and that recruitment is being handled through single-site, investigator-driven settings they believe are better suited to generating high-quality data. On EyeCo, management said it will likely be a private C-Corp that can raise venture or corporate capital, and on POETIC they said the relationship was affected by leadership decisions but still yielded valuable work, especially with Dr. Aru Narendran. They also said Australia is less attractive than mPDAC because a melanoma approval path would likely be larger, longer, and more expensive.
The positive case from this call is that management believes RBS has broad, underappreciated therapeutic potential and that Provectus can monetize it through multiple structures, not just direct drug development. The ophthalmology spinout was presented as a near-term, potentially non-dilutive catalyst, and management said the company may soon see a Phase 3 ophthalmology readout that could validate the asset.
The main risks are that nearly all of the programs are still early, dependent on regulatory steps, and subject to long timelines before any revenue. Management acknowledged prior recruitment problems, delays caused by protocol optimization and partner readiness, and that the canine program has been inefficient, while also saying some pathways like melanoma approval would be too expensive and lengthy to pursue now.
AI summary of the company's earnings call · Paraphrased · Not investment advice
- Free Float
- 92.3%
- Shares Outstanding
- 420.28M
- Float Shares
- 387.87M
of shares held by institutions
4 13F filers
Buy/sell ratio 1.83. Sells can include pre-scheduled 10b5-1 plan sales, not just discretionary selling.
Top institutional holders
Largest 13F positions, with quarter-over-quarter change.
| Holder | Shares | Δ Quarter |
|---|---|---|
| Stancorp Investment Advisers Inc | 14.00K | 0 |
| Lupo Securities, LLC | 3.70K | ▲ 600 |
Recent insider transactions
Who's buying, who's selling, and how much.
| Date | Insider | Type | Shares |
|---|---|---|---|
| Jun 30, 26 | Pershing Edward | other | 45,860 |
| Jun 30, 26 | Rodrigues Dominic | other | 45,860 |
| Jun 30, 26 | Lacey John III | other | 48,917 |
| Jun 30, 26 | Bailey Webster | other | 48,917 |
| Jun 5, 26 | Pershing Edward | other | 9,436 |
| Jun 5, 26 | Pershing Edward | other | 0 |
| May 28, 26 | Pershing Edward | other | 0 |
| May 23, 26 | Pershing Edward | other | 32,089 |
| May 23, 26 | Pershing Edward | other | 0 |
| May 15, 26 | Pershing Edward | other | 22,651 |
A “Sell” may be a pre-scheduled 10b5-1 plan sale rather than a discretionary decision — read insider selling with that in mind.
Our PVCT coverage
Recent articles, reports, and earnings notes.
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Generate PVCT report →VisiRose Selected to Present RB-PDAT at ESCRS iNovation® Day 2026 Emerging Company Showcase
globenewswire.com · Jul 22
Independent University of Lille Study Shows Rose Bengal Sodium Produces Opposing Mechanistic Effects at the Same Dose
globenewswire.com · Jul 7
Provectus Biopharmaceuticals and VisiRose Announce U.S. Patent Award for Light-Independent Antibacterial Eye Drop Targeting Drug-Resistant Ocular Infections
globenewswire.com · Jun 30
Provectus Biopharmaceuticals and VisiRose Announce U.S. Patent Award for Light-Independent Antibacterial Eye Drop Targeting Drug-Resistant Ocular Infections
globenewswire.com · Jun 30
Provectus Biopharmaceuticals Launches Veripure™, an Open Science Program for Medical Research Access to PV-10 (rose bengal sodium)
globenewswire.com · Jun 25
Provectus Biopharmaceuticals, Inc. (PVCT) Shareholder/Analyst Call Transcript
seekingalpha.com · Jun 18
Provectus Biopharmaceuticals Announces Investor Webinar for 2026 Annual Meeting of Stockholders
globenewswire.com · Jun 8
Provectus Biopharmaceuticals Reports Oral PV-10 Anti-Tumor Activity in Preclinical Bladder Cancer Study; Long-Term Survivors Show Absence of Gross Bladder Tumor at Study End
globenewswire.com · May 18
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