Alterity Therapeutics Limited
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About the company
Alterity Therapeutics Limited is engages in research and development of Parkinsonian and neurodegenerative disorders, including Multiple System Atrophy (MSA) and Parkinson's disease. The company's lead drug candidate is ATH434, a small molecule drug candidate that has completed Phase II clinical trial for the treatment of Parkinson's disease. It is also developing ATH434-201, which is in Phase II clinical trial to treat multiple system atrophy early stage; and ATH434-202 that is in Phase II clinical trial to treat multiple system atrophy, as well as biomarkers of progression in multiple system atrophy.
- CEO
- David A. Stamler
- IPO
- 2012
- Employees
- 9
- HQ
- Melbourne, VIC, AU
Price Chart
- Market Cap
- $11.96M
- P/E
- -7.74
- P/S
- 36.03
- P/B
- 2.38
- EV/EBITDA
- -4.43
- Div Yield
- 0.00%
- Gross Margin
- 96.82%
- Op Margin
- -525.58%
- Net Margin
- -380.65%
- ROE
- -30.19%
- ROIC
- -31.32%
- Revenue
- $5.44M · 35.32%
- Net Income
- $-12,147,828 · 36.48%
- EPS
- $-0.10 · 63.46%
- Op Income
- $-14,574,286
- FCF YoY
- 9.20%
- 52W High
- $0.69
- 52W Low
- $0.00
- 50D MA
- $0.06
- 200D MA
- $0.27
- Beta
- 4.81
- Avg Volume
- 176
AI snapshot
Six angles, distilled from the data.
The stock remains in a deep long-term downtrend, trading far below its 200-day average of 0.2744 after a 52-week range of 0.01 to 0.54. The 50-day average sits at 0.055, signaling a flat, compressed base rather than a confirmed recovery trend.
Street sentiment is lightly constructive, with one Buy and no Hold or Sell ratings, but there is no target price to anchor upside. The setup is more watchlist than conviction: no recent rating changes and no fresh price-target action.
Earnings history has been weak, with 0 of the last 8 quarters beating estimates. Losses remain the norm, and the next watchpoint is whether revenue growth can keep translating into a narrower cash burn rather than another miss.
No recent insider transactions were reported, so there is no visible discretionary buying or selling signal. Shareholders should focus instead on clinical progress and financing discipline, since there is no insider pattern to read through.
Profitability is still negative, but gross margin is a strong 97.5%, showing the core economics of the research model can be attractive if development advances. Revenue grew 74.6% year over year, yet operating cash flow was -11.45 million and ROE was -47.0%.
As a micro-cap biotech, PRNAF competes on pipeline optionality rather than current earnings power. Its balance sheet is cleaner than many peers, with 40.66 million in cash and only 155,457 in total debt, but valuation remains tied to clinical execution.
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AI analysis · Last refreshed July 7, 2026 · Live quote · Not investment advice